Pertussis, or whooping cough, is an infectious disease that remains endemic in the United States and Europe despite long-standing vaccines in routine children's immunization programs. Recent American and European studies have demonstrated that pertussis is responsible for a significant proportion of persistent cough in adolescents, even in those who received childhood vaccination.
In 2007, the Pentaxim® vaccine for immunization against diphtheria, tetanus, pertussis, polio, and Haemophilus influenzae type b (Hib) was granted market authorization in Mexico. The vaccine is currently administered to all infants at 2, 4, 6 and 18 months with a booster at 4 years. To determine if the booster could be of use for adolescents as well, information on disease burden is needed.
In 2008, AMP teamed up with the National Institute of Medical Sciences and Nutrition (INCMNSZ) in Mexico City to determine the incidence of pertussis among adolescents between 11 to 16 years of age in southwestern Mexico City.
Using a cohort of 13,000 adolescents aged 12 to 16 years old enrolled in a random sample of Mexico City schools, the study revealed a high incidence of pertussis as a cause of mild to severe cough. As a result, strategies for pertussis prevention and control should be targeted at this age group.
Main Achievements in 2011:
- AMP, the Mexican Ministry of Health, and the Mexican National Institute of Medical Sciences and Nutrition organized a one-day international workshop on pertussis in adolescents on April 7, 2011 in Mexico City
- Final study report for funder completed titled: “A prospective cohort study of pertussis in adolescents attending middle school in Mexico City, Mexico”
- Poster presentation at the 7th World Congress of the World Society for Pediatric Infectious Diseases in Melbourne, Australia
- Submission of a manuscript titled: “Estimating the burden of pertussis in Mexican adolescents from paired serological data using a bivariate mixture model” to the Journal of the American Statistical Association (paper is currently under review)
- Preparation of main study manuscript