Image of pertussis study in Mexico City

Pertussis, or whooping cough, is an infectious disease that remains endemic in the United States and Europe despite long-standing vaccines in routine children's immunization programs. Recent American and European studies have demonstrated that pertussis is responsible for a significant proportion of persistent cough in adolescents, even in those who received childhood vaccination.

In 2007, the Pentaxim® vaccine for immunization against diphtheria, tetanus, pertussis, polio, and Haemophilus influenzae type b (Hib) was granted market authorization in Mexico. The vaccine is currently administered to all infants at 2, 4, 6 and 18 months with a booster at 4 years. To determine if the booster could be of use for adolescents as well, information on disease burden is needed.

In 2008, AMP teamed up with the National Institute of Medical Sciences and Nutrition (INCMNSZ) in Mexico City to determine the incidence of pertussis among adolescents between 11 to 16 years of age in southwestern Mexico City.

Using a cohort of 13,000 adolescents aged 12 to 16 years old enrolled in a random sample of Mexico City schools, the study revealed a high incidence of pertussis as a cause of mild to severe cough. As a result, strategies for pertussis prevention and control should be targeted at this age group. 

Main Achievements in 2011: